pantoprazole protonix
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Pantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance. Pantoprazole is relatively free of drug interactions…
The Food and Drug Administration (FDA) has approved Wyeth’s Protonix (pantoprazole) …
Wyeth has received FDA approval of a new formulation for Protonix I.V. The reformulation provides for …
American Home Products Corporation (NYSE: AHP) announced today that the U.S. Food And Drug Administration (FDA) has approved an impo
Wyeth (NYSE: WYE) announced that PROTONIX(R) (pantoprazole sodium) Delayed-Release Tablets were approved by the U.S. Food and Drug Administration (FDA) for the long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison Syndrome, on April 19, 2002. PROTONIX(R) is the first and only proton pump inhibitor (PPI) with both oral and intravenous (IV) formulations approved in the U.S. for the treatment of this chronic and potentially fatal disease. PROTONIX(R) I.V. was approved for treatment of this condition on October 19, 2001. PROTONIX(R) is marketed in the U.S. by Wyeth Pharmaceuticals.
“Zollinger-Ellison Syndrome is a painful and potentially deadly disease,” says Victoria Kusiak, M.D., Vice President and Medical Director for Wyeth Pharmaceuticals North America. “Both PROTONIX(R) I.V. and tablets are now approved for this condition. Patients can now use the tablets for their long-term treatment and can be treated with the I.V. formulation for up to six days when appropriate.”
About Zollinger-Ellison Syndrome
Zollinger-Ellison Syndrome is a rare disease typically affecting people between the ages of 30 and 50. It is caused by a neuroendocrine tumor called a gastrinoma that is usually located in the pancreas or the duodenum, a portion of the small intestine. As a result of the tumor, there are high circulating levels of the hormone gastrin, which result in the stimulation of the parietal cell to produce excessive levels of gastric acid secretion. Zollinger-Ellison patients often suffer from severe ulceration of the upper gastrointestinal tract. Symptoms of Zollinger-Ellison Syndrome include burning pain in the abdomen, diarrhea, nausea, fatigue, and weight losProtonix tablet
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